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KMID : 1140120050100020102
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Cancer Prevention Research
2005 Volume.10 No. 2 p.102 ~ p.110
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Bioregulation of Helicobacter pylori Infection with Red Ginseng; Double Blinded Randomized Controlled Trial (DB-RCT)
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Hahm Ki-Baik
Park Su-Jin
Kwak Mi-Sun
Lee Jeong-A
Kim Young-Bae
Chung Jae-Yong
Lee Ki-Myung
Kim Duck-Ki
Kim Dong-Kyu
Cho Sung-Won
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Abstract
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The fact that mass eradication of Helicobacter pylori (H. pylori) can not be recommended as a cost-effective means to prevent the development of gastric cancer, although H. pylori was defined as class I carcinogen and cohort study confirmed H. pylori as causative bacteria responsible for gastric carcinogenesis drives us to search for the way either to kill bacteria or lessen gastric inflammations. Since our previous study suggested red ginseng capsule could be candidate, randomized controlled trial was done to document the efficacy of 10-week supplementation of red ginseng capsules (2.7 g/day) after triple therapy for eradication compared to that of the placebo supplementation. Total 84 patients were enrolled and 70 patients completed the trial (83.3% PP). The eradication rates were statistically significantly augmented in red ginseng group compared to placebo group (79.4% in placebo group and 91.7% in red ginseng group, p＜0.05). In respective analysis of gastritis, red ginseng group showed statistically significant improvement in neutrophil infiltrations, mononuclear cell infiltrations, gastric atrophy, and even intestinal metaplasia than placebo group (p＜0.05). H. pylori infection was associated with significant generation and nuclear translocation of 8-OHdG, but red ginseng group was excellent in lessening 8-OHdG generations in parallel with attenuated apoptosis and single cell nuclear damages than placebo group (p＜0.05). Conclusively, red ginseng supplementary treatment after H. pylori eradication was beneficial in either quantitative or qualitative aspect for H. pylori infection and the considerable cytoprotective properties and anti-inflammatory activities of red ginseng might contribute to the treatment of H. pylori-associated chronic gastritis.
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KEYWORD
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Helicobacter pylori, Gastric cancer, Chemoprevention, Red ginseng, 8-OHdG
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